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Endocrine Disruption

Bisphenol A


Bisphenol A (BPA), a synthetic chemical with estrogen-like effects, is used in products such as baby bottles, water bottles, eyeglass lenses, medical equipment, toys, CDs/DVDs, cell phones, consumer electronics, household appliances, sports safety equipment, airplanes, and automobiles. Epoxy resins containing BPA are used as liners for most food and beverage cans, adhesives, industrial protective coatings, and automotive primers. BPA is also used to make dental sealants, flame retardants, and is an additive in many other widely used consumer products.

The human body can metabolize and excrete BPA relatively rapidly. Yet a recent study by the U.S. Centers for Disease Control and Prevention, that looked at urinary concentrations of BPA in over 2500 participants, indicated that 93% of U.S. residents have measurable amounts of BPA in their bodies. This suggests that human exposure is continuous and via multiple sources.

TEDX has three projects addressing BPA:

BPA in humans

TEDX's comprehensive review Bisphenol A and Human Health: A Review of the Literature was accepted for publication in the peer-reviewed scientific journal Reproductive Toxicology in August, 2013. Associations were revealed between Bisphenol A exposure and adverse perinatal, childhood and adult health outcomes in humans, including reproductive and developmental effects, metabolic disease and other health outcomes, particularly behavioral effects in children. These studies, over half of which were published in the last year, confirm that BPA can be harmful to humans at levels experienced by the general population, and well below levels considered safe by the EPA. 

Low dose BPA research

TEDX’s Low Dose Bisphenol A Project is an analysis of the scientific studies that examined the effects of BPA at 1 ppm (1 mg/kg/day) or less. In addition to an EXCEL spreadsheet (which can be downloaded, searched and sorted as needed), we provide a summary, graphs and additional analyses.

Prenatal exposure to BPA  

TEDX's Critical Windows of Development interactive website tool presents a timeline of how the human body develops in the womb, with animal research showing when low dose exposure to endocrine disrupting chemicals during development results in altered health outcomes. BPA is one of several chemicals presented in the Critical Windows of Development tool.

BPA Resources:

Click here to link to a news article and published report on why BPA deserves a new risk assessment.

Click here for a published commentary on Good Laboratory Practices and BPA (PDF).

Click here for a detailed report on the continuing debate over the effects of BPA, written by Sarah Vogel, PhD.

Six Classes - Endocrine Disruptors in Plastic: Bisphenol A & Phthalates, presented by Dr. Carol Kwiatkowski, is part of a video series of half-hour webinars about six families or “classes” of chemicals which contain many of the harmful substances found in everyday products. (28 min., November 2013, hosted by Green Science Policy Institute)