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Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

How and Why We Created the TEDX List

TEDX List of Potential Endocrine Disruptors

As early as 1988, before the term endocrine disruption was used, TEDX founder Theo Colborn began collecting scientific literature on chemicals that could interfere with function, development and reproduction, particularly on chemicals that had effects at ambient concentrations in wildlife. Today, TEDX’s collection of endocrine disruption literature has grown to over 52,000 documents, including thousands of scientific studies that demonstrate impairment of the endocrine system.

As individuals, governments, and non-profit organizations have increasingly begun to pay attention to endocrine disruption, TEDX has received numerous requests for a list of potential endocrine disruptors. As a starting point in developing the TEDX List we drew from two other comprehensive lists1, as well as additional original research contained in our in-house literature database.

In the TEDX List, every citation refers to a primary research study that we acquired and read. The number of citations presented in the TEDX List does not necessarily reflect the amount of research that has been done on each chemical and should not be used to prioritize chemicals.

To address the problem of chemicals with numerous synonyms, the TEDX List includes unique CAS2 numbers (wherever possible), commonly used alternative names, and consistent nomenclature for chemical classes with multiple congeners.

Use and source information was obtained by searching chemical CAS numbers primarily within government databases that are compiled and maintained by the U.S. National Library of Medicine. Databases included the Hazardous Substances Data Bank (HSDB), Haz-Map, and the Household Products Database. If the CAS number was not found in these databases other sources were searched, including government documents such as those from the USEPA Agency for Toxic Substances and Disease Registry (ATSDR), primary peer-reviewed literature, the Compendium of Pesticide Common Names, PAN pesticide database, manufacturer information, and patent information.

Although we update the TEDX List regularly, use and source information may not be current or comprehensive for several reasons: it is difficult to ascertain every use of a given chemical, product formulations and pesticide registration status can change, and a few chemicals could not be categorized (for example, metabolites).

 

1 IEH. 2005. Chemicals purported to be endocrine disrupters. A compilation of published lists. Leicester, UK: MRC Institute for Environment and Health. (Web Report W20). Accessible at: http://www.cranfield.ac.uk/about/people-and-resources/schools-and-departments/school-of-applied-sciences/groups-institutes-and-centres/ieh-reports-/endocrine-disruptors/w20.pdf

  BKH Consulting Engineers, TNO Nutrition and Food Research. 2000. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption. Final Report (incorporating corrigenda to final report dated 21 June 2000).: European Commission DG ENV. M0355008/1786Q/10/11/00. Accessible at: http://ec.europa.eu/environment/archives/docum/pdf/bkh_main.pdf

2 The American Chemical Society has established the Chemical Abstracts Service (CAS) number system to identify unique chemical substances. A single substance can have many different names, but only one CAS number.