The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased percentage with onset of eye opening at 15 days of age; increased successful righting reflex at 5 and 6 days of age; increased successful cliff-drop aversion reflex at 7 days of age at higher dose; decreased ability to stay on a rotating rod

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 1.0 μg/kg bw

Other doses tested: Initial dose was followed by weekly maintenance doses (at 40 percent)

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – adulthood (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Thiel R, Koch E, Ulbrich B, Chahoud I. 1994. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin - effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69(2):79-86.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased percentage of eyes opened at 12 through 15 days of age

Subjects: Line C (highly sensitive to TCDD) rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11)

Age of measurement: 40 days of age

Reference [PubMed Link]
Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased (delayed) eye opening at 15 days of age

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 1.0 μg/kg bw initial dose, with 0.4 or 0.12 μg/kg weekly maintenance doses

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – at 5 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth)

Age of measurement: 7 through 31 days of age

Reference
Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231.