The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased brain weight

Subjects: Long Evans hooded rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: in late adulthood

Reference [PubMed Link]
Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. 1995. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology & Applied Pharmacology 131(1):108-118.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased response rates in males and increased response rates in females performing schedule-controlled food-reinforced operant procedures

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.02, 0.6 or 0.18 μg/kg

Route of administration: dissolved in olive oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: birth through young adulthood

Reference [PubMed Link]
Hojo R, Stern S, Zareba G, Markowski VP, Cox C, Kost JT, Weiss B. 2002. Sexually dimorphic behavioral responses to prenatal dioxin exposure. Environ Health Perspect 110(3):247-254.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased relative number of smallest cortical cell size and decreased relative number of larger cortical cells in males in-bregma -3.8 mm of area 17 and 18a in left hemisphere; increased relative number of smallest cortical cell size and decreased relative number of larger cortical cells in males in-bregma -3.8 mm of area 17 in right hemisphere; increased relative number of Class 6 cortical cells in females in area 17 of left hemisphere

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.18 μg/kg

Route of administration: dissolved in olive oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: 90 days of age

Reference [PubMed Link]
Hojo R, Zareba G, Kai JW, Baggs RB, Weiss B. 2006. Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxin. J Appl Toxicol 26(1):25-34.