The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased CYP1A1 mRNA levels on post-natal day 2

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg

Route of administration: delivered subcutaneously

Exposure duration: post-natal day 2 – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22)

Age of measurement: 70 days of age

Reference [PubMed Link]
Ohsako S, Miyabara Y, Sakaue M, Ishimura R, Kakeyama M, Izumi H, Yonemoto J, Tohyama C. 2002. Developmental stage-specific effects of perinatal 2,3,7,8- tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring. Toxicol Sci 66(2):283-292.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased percentage of eyes opened at 12 through 14 days of age

Subjects: Line C (highly sensitive to TCDD) rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: 2 days of age – single dose (comparable to human prenatal development from approximately day 1 of week 21 to day 1 of week 22)

Age of measurement: 40 days of age

Reference [PubMed Link]
Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66.