The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased pH3 expression and increased external granular layer thickness on post-natal day 10. Decreased BrdU indicating a reduced number of granule neuroblasts on post-natal day 10. Increased Bax expression on post-natal days 8 and 10 with increased levels and abnormal patterns of apoptsis. Reduced DNA content and GABARAα6 in cerebellar tissue collected post-natal day 21

Subjects: C57BL/6J mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in olive oil and administered by gavage

Exposure duration: post-natal day 6 – single dose (comparable to human prenatal development from approximately day 1 of week 22 to day 1 of week 23)

Age of measurement: post-natal days 7, 8, 10, and 21

Reference [PubMed Link]
Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. 2008. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol Sci 103(1):125-136.