The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased percentage of eyes opened at 11 through 15 days of age

Subjects: Line C (highly sensitive to TCDD) rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: 40 days of age

Reference [PubMed Link]
Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased expression of insulin-like growth factor binding protein 5 (IGFBP5) mRNA

Subjects: C57BL/6J mice

Chemical: Dioxin (TCDD)

Low doses tested: 5.0 μg/kg

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: gestational day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: gestational day 18.5

Reference [PubMed Link]
Tanaka J, Yonemoto J, Zaha H, Kiyama R, Sone H. 2007. Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems. Molecular & Cellular Endocrinology 272(1-2):38-49.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased whole brain mRNA levels of Cyp1b1, Cxcl4, and Cxcl7 at various time points in both males and females with mRNA decreases in Cxcl5 and Ccl22.

Subjects: C57BL/6N mice

Chemical: Dioxin (TCDD)

Low doses tested: 5.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 12.5 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: gestational days 15.5 and 18.5 and on post-natal days 1, 5 and 21

Reference [PubMed Link]
Mitsui T, Taniguchi N, Kawasaki N, Kagami Y, Arita J. 2011. Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain. J Appl Toxicol 31(3):279-284.