The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Dose related decrease in earned opportunities to run, lever response rate, and total revolutions in the running wheel task

Subjects: Holtzman rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.02, 0.6 or 0.18 μg/kg

Route of administration: dissolved in olive oil and delivered through gavage

Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)

Age of measurement: birth through young adulthood

Reference [PubMed Link]
Markowski VP, Zareba G, Stern S, Cox C, Weiss B. 2001. Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 109(6):1-7.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased number of viable cells and increased number of apoptotic cortical cells from 1 day old pups. Decreased K+ evoked extracellular glutamate levels in 1, 14, and 60 day old rats. Decreased glutamate uptake in cerebral cortical cells in 14 and 60 day old rats.

Subjects: Dark-Agouti rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.7 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)

Age of measurement: post-natal days 1, 14 and 60

Reference [PubMed Link]
Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766.