The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DEHP)

Increased escape latency and decreased time spent in removed quadrant on the Morris water-maze test.

Subjects: Sprague Dawley rats

Chemical: Phthalates (DEHP)

Low doses tested: 1.25 mg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 2 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 16)

Age of measurement: 19, 21 and 22 months

Reference [PubMed Link]
Sun W, Ban JB, Zhang N, Zu YK, Sun WX. 2012 May 19 (in press). Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol .
Study Results Study Details References

Results for Phthalates (DEHP)

Alterations in the expression of hippocampal insulin, IGF-I, IGF-II, bim, bad, p-GSK-3β, and p-Akt. Increased levels of phosphorylated tau in the hippocampus.

Subjects: Sprague Dawley rats

Chemical: Phthalates (DEHP)

Low doses tested: 1.25 mg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 2 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 16)

Age of measurement: 19, 21 and 22 months

Reference [PubMed Link]
Sun W, Ban JB, Zhang N, Zu YK, Sun WX. 2012 May 19 (in press). Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol .