The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DBP, DCHP and DEHP)

Increased nightime hyperactivity at 4 weeks of age

Subjects: Wistar rats

Chemical: Phthalates (DBP, DCHP and DEHP)

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 4 and 8 weeks of age

Reference [PubMed Link]
Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153.
Study Results Study Details References

Results for Phthalates (DBP, DCHP and DEHP)

Decreased gene expression of dopamine transporter in the midbrain

Subjects: Wistar rats

Chemical: Phthalates (DBP, DCHP and DEHP)

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 4 and 8 weeks of age

Reference [PubMed Link]
Ishido M, Morita M, Oka S, Masuo Y. 2005. Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept 126(1-2):145-153.
Study Results Study Details References

Results for Phthalates (DCHP)

Increased hyperactivity at 4 weeks of age

Subjects: Wistar rats

Chemical: Phthalates (DCHP)

Low doses tested: 87 nmol/10 μl/rat(~10 g)

Route of administration: injected intracisternally into pups

Exposure duration: post-natal day 5 – single dose (comparable to human prenatal development from approximately day 1 of week 25 to day 1 of week 26)

Age of measurement: 4 and 8 weeks of age

Reference [PubMed Link]
Ishido M, Masuo Y, Sayato-Suzuki J, Oka S, Niki E, Morita M. 2004 Oct. Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity. J Neurochem 91(1):69-76.