The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Decreased percentage of embryos developing to blastocycts; increased percentage of apoptosis; decreased mean cell number per embryo

Subjects: CD-1 mice

Chemical: Chlorpyrifos

Low doses tested: 0.003 μg/ml

Route of administration: dissolved in ethanol and delivered in vitro

Exposure duration: gestational day 0 – gestational day 4 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 2)

Age of measurement: in vitro after 96 hours in culture

Reference [PubMed Link]
Greenlee AR, Ellis TM, Berg RL. 2004. Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environ Health Perspect 112(6):703-709.
Study Results Study Details References

Results for Chlorpyrifos

Decreased performance on inclined plane in females; decreased forepaw grip time in males and females

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 mg/kg bw/d

Route of administration: dissolved in ethanol and delivered dermally

Exposure duration: gestational day 4 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 14)

Age of measurement: 90 days of age

Reference [PubMed Link]
Abou-Donia MB, Khan WA, Dechkovskaia AM, Goldstein LB, Bullman SL, Abdel-Rahman A. 2006. In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. Arch Toxicol 80(9):620-631.
Study Results Study Details References

Results for Chlorpyrifos

Increased activity of acetylcholinesterase (AChE) in brainstem and cerebellum of females only; decreased density of surviving Purkinje cells; increased glial fibrillary acidic protein (GFAP) structures in the granular cell layer and white matter of the cerebellum

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 mg/kg bw/d

Route of administration: dissolved in ethanol and delivered dermally

Exposure duration: gestational day 4 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 14)

Age of measurement: 90 days of age

Reference [PubMed Link]
Abou-Donia MB, Khan WA, Dechkovskaia AM, Goldstein LB, Bullman SL, Abdel-Rahman A. 2006. In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. Arch Toxicol 80(9):620-631.