The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Decreased caudate-putamen thickness among females at 5 mg/kg; decreased parietal cortex layer thickness among females at 1 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 0.3, 1.0, or 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 31)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Maurissen JPJ, Hoberman AM, Garman RH, Hanley TR. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol Sci 57(2):250-263.
Study Results Study Details References

Results for Chlorpyrifos

Decreased absolute brain weight and increased brain-to-body weight ratio at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 0.3, 1.0, or 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 31)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Maurissen JPJ, Hoberman AM, Garman RH, Hanley TR. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol Sci 57(2):250-263.
Study Results Study Details References

Results for Chlorpyrifos

Decreased cerebellum length and height among males at 5 mg/kg; decreased cerebellum height among females at 1 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 0.3, 1.0, or 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 31)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Maurissen JPJ, Hoberman AM, Garman RH, Hanley TR. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol Sci 57(2):250-263.
Study Results Study Details References

Results for Chlorpyrifos

Decreased brain cholinesterase (ChE) specific activity at 1 and 3 days of age; decreased M1/M3 mAChR binding at 1 day of age; decreased high affinity choline uptake (HACU) transporter levels at 6 days of age

Subjects: Sprague-Dawley (Crl:CD(5D) BR) rats

Chemical: Chlorpyrifos

Low doses tested: 3.0 mg/kg bw/d

Other doses tested: 7.0 mg/kg bw/d

Route of administration: dissolved in corn oil and fed on a cookie

Exposure duration: gestational day 6 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 14)

Age of measurement: 1, 3, 6, 9, 12, and 30 days of age

Reference [PubMed Link]
Richardson JR, Chambers JE. 2004. Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. Toxicol Sci 77(1):83-90.
Study Results Study Details References

Results for Chlorpyrifos

Decreased dopamine levels in the cerebral cortex on gestational day 17 and on post-natal day 14

Subjects: ICR mice

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 7.5 – gestational day 11.5 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 6)

Age of measurement: gestational day 17 and post-natal days 14 and 60

Reference [PubMed Link]
Chen XP, Wang X, Dong JY. 2011. Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods. J Appl Toxicol 31(4):355-359.
Study Results Study Details References

Results for Chlorpyrifos

Decreased dopamine levels in the hippocampus on post-natal days 14 and 60

Subjects: ICR mice

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 7.5 – gestational day 11.5 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 6)

Age of measurement: gestational day 17 and post-natal days 14 and 60

Reference [PubMed Link]
Chen XP, Wang X, Dong JY. 2011. Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods. J Appl Toxicol 31(4):355-359.