The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Increased locomotion; increased push-under (soliciting) response; increased agonistic responses among males

Subjects: CD-1 mice

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 3.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected sub-cutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 28 to day 1 of week 32)

Age of measurement: through adulthood

Reference [PubMed Link]
Ricceri L, Markina N, Valanzano A, Fortuna S, Cometa MF, Meneguz A, Calamandrei G. 2003. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicology & Applied Pharmacology 191(3):189-201.
Study Results Study Details References

Results for Chlorpyrifos

Increased frequency and duration of attack response at 3 mg/kg day; increased frequency and duration of crouching (maternal behavior); decreased frequency of licking; increased duration of licking; decreased frequency and duration of sniffing; increased time spent in open arms of plus-maze for females at 3.0 mg/kg

Subjects: CD-1 mice

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 3.0 mg/kg bw/d

Route of administration: dissolved in peanut oil and injected sub-cutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 28 to day 1 of week 32)

Age of measurement: 60 through 120 days of age

Reference [PubMed Link]
Ricceri L, Venerosi A, Capone F, Cometa MF, Lorenzini P, Fortuna S, Calamandrei G. 2006. Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol Sci 93(1):105-113.
Study Results Study Details References

Results for Chlorpyrifos

Decreased locomotor activity during the first session of a social recognition test; increased latency in building the nest in pregnant females; decreased latency of first maternal licking; shorter latency to enter the light compartment during the dark-light test; decreased frequency of aggressive attacks and increased social investigation toward a male intruder; increased frequency of digging behavior.

Subjects: CD-1 mice

Chemical: Chlorpyrifos

Low doses tested: 3.0 mg/kg bw/d

Route of administration: dissolved in peanut oil and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 28 to day 1 of week 32)

Age of measurement: adolescence and adulthood

Reference [PubMed Link]
Venerosi A, Cutuli D, Colonnello V, Cardona D, Ricceri L, Calamandrei G. 2008. Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood. Neurotoxicology & Teratology 30(6):468-474.