The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Decreased ChE, MAGL, and FAAH in the forebrain

Subjects: Sprague Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.5, and 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: post-natal day 10 – post-natal day 16 (comparable to human prenatal development from approximately day 1 of week 30 to day 1 of week 37)

Age of measurement: post-natal day 16

Reference [PubMed Link]
Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA. 2012. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol 34(4):614-621.
Study Results Study Details References

Results for Chlorpyrifos

Decreased ChE in the medulla-pons

Subjects: Sprague Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.5, and 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: post-natal day 10 – post-natal day 16 (comparable to human prenatal development from approximately day 1 of week 30 to day 1 of week 37)

Age of measurement: post-natal day 16

Reference [PubMed Link]
Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA. 2012. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol 34(4):614-621.
Study Results Study Details References

Results for Chlorpyrifos

Decreased ChE, MAGL, and FAAH in the forebrain

Subjects: Sprague Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.5, and 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: post-natal day 10 – post-natal day 16 (comparable to human prenatal development from approximately day 1 of week 30 to day 1 of week 37)

Age of measurement: post-natal day 16

Reference [PubMed Link]
Carr RL, Borazjani A, Ross MK. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122(1):112-120.
Study Results Study Details References

Results for Chlorpyrifos

Decreased ChE in the medulla-pons

Subjects: Sprague Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.5, and 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: post-natal day 10 – post-natal day 16 (comparable to human prenatal development from approximately day 1 of week 30 to day 1 of week 37)

Age of measurement: post-natal day 16

Reference [PubMed Link]
Carr RL, Borazjani A, Ross MK. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122(1):112-120.