The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Increased lose-shift errors in T-maze delayed-alternation task in both males and females treated gestationally with 5.0 mg/kg. With a gradual increase in the number of errors in males at the longest delay time of 60 seconds.

Subjects: ICR mice

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9)

Age of measurement: post-natal day 45 through post-natal day 60

Reference [PubMed Link]
Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28.
Study Results Study Details References

Results for Chlorpyrifos

Decreased number of cells in Prl and IL regions of the medial prefrontal cortex in both males and females treated with 5.0 mg/kg.

Subjects: ICR mice

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9)

Age of measurement: post-natal day 45 through post-natal day 60

Reference [PubMed Link]
Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28.
Study Results Study Details References

Results for Chlorpyrifos

Decreased number of cells in CA1, DG, and CA3 regions of the dorsal hippocampus in males and in the DG in females treated with 5.0 mg/kg.

Subjects: ICR mice

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9)

Age of measurement: post-natal day 45 through post-natal day 60

Reference [PubMed Link]
Chen XP, Chen WZ, Wang FS, Liu JX. 2012. Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure. Brain Res 1474:19-28.
Study Results Study Details References

Results for Chlorpyrifos

Decreased dopamine levels in the cerebral cortex on post-natal days 14 and 60

Subjects: ICR mice

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 13 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 9)

Age of measurement: gestational day 17 and post-natal days 14 and 60

Reference [PubMed Link]
Chen XP, Wang X, Dong JY. 2011. Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods. J Appl Toxicol 31(4):355-359.