The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for PFCs (K+PFOS)

Decreases in total activity at 2 months of age.

Subjects: NMRI mice

Chemical: PFCs (K+PFOS)

Low doses tested: 0.75 mg/kg bw

Other doses tested: 11.3 mg/kg

Route of administration: dissolved in a mixture of egg lecithin and peanut oil and delivered via metal gastric tube

Exposure duration: post-natal day 10 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 27 to day 1 of week 28)

Age of measurement: 2 and 4 months of age

Reference [PubMed Link]
Johansson N, Fredriksson A, Eriksson P. 2008. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology 29(1):160-169.
Study Results Study Details References

Results for PFCs (PFOA)

Decreases in total activity and locomotion at 4 months; changes in activity compared to controls in response to nicotine. Increases in rearing in those dosed at 0.58 mg/kg PFOA at 2 and 4 months of age.

Subjects: NMRI mice

Chemical: PFCs (PFOA)

Low doses tested: 0.58 mg/kg bw

Other doses tested: 8.7 mg/kg bw

Route of administration: dissolved in a mixture of egg lecithin and peanut oil and delivered via metal gastric tube

Exposure duration: post-natal day 10 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 27 to day 1 of week 28)

Age of measurement: 2 and 4 months of age

Reference [PubMed Link]
Johansson N, Fredriksson A, Eriksson P. 2008. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology 29(1):160-169.