The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased age at vaginal opening at low and high doses; increased estrus length at low and middle doses; decreased uterine weight at highest dose

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.025, 0.060, 0.3 μg/kg bw

Other doses tested: Initial dose was followed by weekly maintenance doses (at 20 percent)

Route of administration: injected subcutaneously

Exposure duration: pre-conception – post-natal day 22 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Faqi AS, Dalsenter PR, Merker HJ, Chahoud I. 1998. Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicology & Applied Pharmacology 150(2):383-392.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased Ahr in immunochemical staining of uterine tissue in F1, F2 and F3 generations. Increased uterine Cyp1a2 expression in the F1 generation.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 2.0 ng/L

Route of administration: dissolved in DMSO and delivered in drinking water

Exposure duration: gestational day 0 – daily in drinking water (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: post-natal day 1, 4, 21, and 35

Reference [PubMed Link]
Huang L, Huang R, Ran XR, Liu HY, Zhang Y, Dai LJ, Li B. 2011. Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality. J Toxicol Sci 36(6):713-724.