The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased urethral slit; decreased urethral-vaginal distance; increased cyctic hyperplasia of the endometrium; increased inflammatory lesions of the cervix

Subjects: Long Evans hooded rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. 1995. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology & Applied Pharmacology 131(1):108-118.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased incidence of constant estrous by middle age (about 1 year old); decreased fertility

Subjects: Long Evans hooded rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. 1995. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology & Applied Pharmacology 131(1):108-118.