The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for PFCs (PFOA)Epithelial branching and longitudinal growth of the mammary gland were sigificantly stunted.
Subjects: CD-1 mice
Chemical: PFCs (PFOA)
Low doses tested: 5.0 mg/kg bw/d
Route of administration: dissolved in deionized water and delievered through gavage
Exposure duration: gestational day 12 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 9)
Age of measurement: post-natal days 1, 5, 10, 20
|Reference [PubMed Link]
White SS, Calafat AM, Kuklenyik Z, Villanueva L, Zehr RD, Helfant L, Strynar MJ, Lindstrom AB, Thibodeaux JR, Wood C, Fenton SE. 2007. Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicol Sci 96(1):133-144.