The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased sperm number from cauda epididymis and daily sperm production in puberty and adulthood; increased sperm transit rate in puberty and adulthood; increased percent of abnormal sperm in adulthood

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.025, 0.060, 0.3 μg/kg bw

Other doses tested: Initial dose was followed by weekly maintenance doses (at 20 percent)

Route of administration: injected subcutaneously

Exposure duration: pre-conception – post-natal day 22 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Faqi AS, Chahoud I. 1998. Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation. Bulletin of Environmental Contamination & Toxicology 61(4):462-469.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased ventral prostate weight at 28 and 120 days of age;

Subjects: Holtzman rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.4 μg/kg bw

Other doses tested: Initial dose was followed by weekly maintenance doses of 0.08 μg/kg during mating, pregnancy, and lactational periods

Route of administration: delivered orally via gavage

Exposure duration: preconception – weaning (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Ikeda M, Tamura M, Yamashita J, Suzuki C, Tomita T. 2005. Repeated in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure affects male gonads in offspring, leading to sex ratio changes in F-2 progeny. Toxicology & Applied Pharmacology 206(3):351-355.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased time to balano-preputial separation (BPS) at 42 to 70 days of age

Subjects: Wistar(Han) rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.0028, 0.0093 or 0.053 μg/kg/day

Route of administration: delivered in daily diet

Exposure duration: 12 weeks prior to mating – birth (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through 120 days of age

Reference [PubMed Link]
Bell DR, Clode S, Fan MQ, Fernandes A, Foster PMD, Jiang T, Loizou G, Macnicoll A, Miller BG, Rose M, Tran L, White S. 2007. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99(1):224-233.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased proportion of abnormal sperm, mean total homogenization resistant spermatid count, and ratio of testes weight to body weight on day 70 at 0.053 μg/kg/day

Subjects: Wistar(Han) rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.0028, 0.0093 or 0.053 μg/kg/day

Route of administration: delivered in daily diet

Exposure duration: 12 weeks prior to mating – birth (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through 120 days of age

Reference [PubMed Link]
Bell DR, Clode S, Fan MQ, Fernandes A, Foster PMD, Jiang T, Loizou G, Macnicoll A, Miller BG, Rose M, Tran L, White S. 2007. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99(1):224-233.