The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased ano-genital distance/body length on post-natal day 30

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 15 to day 1 of week 21)

Age of measurement: post-natal days 7, 21, 30 and 60

Reference [PubMed Link]
Jin MH, Hong CH, Lee HY, Kang HJ, Han SW. 2010. Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: involvement of antioxidants, oxidants, and p53 protein. Environ Toxicol 25(1):1-8.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative testes and epididymal weights on post-natal day 60. Decreased sperm count on post-natal day 60 and decreased testosterone, SOD, CAT, and GR activity with increased H2O2 levels on post-natal days 30 and 60. Increased testicular p53 and Bax on post-natal days 30 and 60.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 15 to day 1 of week 21)

Age of measurement: post-natal days 7, 21, 30 and 60

Reference [PubMed Link]
Jin MH, Hong CH, Lee HY, Kang HJ, Han SW. 2010. Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: involvement of antioxidants, oxidants, and p53 protein. Environ Toxicol 25(1):1-8.