The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased relative testicular weight at 17 days of age; increased diameter of seminiferous tubules at 17 days of age; increased expression of ERα mRNA at 17 days of age; increased expression of ERβ mRNA at 42 days of age

Subjects: Slc. Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.01 μg/kg bw in 5 weekly doses

Route of administration: administered sub-cutaneously

Exposure duration: gestational day 7 – 5 weekly doses (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: 17 and 42 days of age

Reference [PubMed Link]
Ohyama K, Ohta M, Sano T, Sato K, Nakagomi Y, Shimura Y, Yamano Y. 2007. Maternal exposure of low dose of TCDD modulates the expression of estrogen receptor subunits of male gonads in offspring. J Vet Med Sci 69(6):619-625.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased age at preputial separation (puberty)

Subjects: Long Evans Hooded rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Gray LE, Wolf C, Mann P, Ostby JS. 1997. In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans Hooded rat offspring. Toxicology & Applied Pharmacology 146(2):237-244.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased ejaculated sperm count

Subjects: Long Evans Hooded rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Gray LE, Wolf C, Mann P, Ostby JS. 1997. In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans Hooded rat offspring. Toxicology & Applied Pharmacology 146(2):237-244.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased expression of steroidogenic acute regulatory protein mRNA (StAR) and steroidogenic enzyme cytochrome P450 11A1 and 17 in fetal testis

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: gestational day 8 – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: gestational day 20

Reference [PubMed Link]
Mutoh J, Taketoh J, Okamura K, Kagawa T, Ishida T, Ishii Y, Yamada H. 2006. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Endocrinology 147(2):927-936.