The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased AhR protein concentration (but not ARNT) in the ventral and dorsolateral prostate

Subjects: Holtzman rats

Chemical: Dioxin (TCDD)

Low doses tested: 5.0 μg/kg bw

Route of administration: injected intraperitoneally

Exposure duration: post-natal day 6 – single dose (comparable to human prenatal development from approximately day 1 of week 26 to day 1 of week 27)

Age of measurement: 6 days of age

Reference [PubMed Link]
Sommer RJ, Sojka KM, Pollenz RS, Cooke PS, Peterson RE. 1999. Ah receptor and arnt protein and mRNA concentrations in rat prostate: Effects of stage of development and 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment. Toxicology & Applied Pharmacology 155(2):177-189.