The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased expression of testicular steroid acute regulatory protein (StAR) mRNA at 0.2μg/kg; increased diameter of infant testis seminiferous cord at 0.04 μg/kg

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.04, 0.20, or 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: 14 days of age

Reference [PubMed Link]
Haavisto TE, Myllymaki SA, Adamsson NA, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2006. The effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on testicular steroidogenesis in infantile male rats. Int J Androl 29(2):313-322.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased relative testis weight at 1.0 μg/kg at 12 days of age and at 0.2 μg/kg at 14 days of age

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.04, 0.2 or 1.0 μg/kg bw

Route of administration: dissolved in corn oil, sonicated, and delivered via gavage

Exposure duration: gestational day 13 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: 10 through 16 days of age

Reference [PubMed Link]
Myllymaki SA, Haavisto TE, Brokken LJS, Viluksela M, Toppari J, Paranko J. 2005. In utero and lactational exposure to TCDD; Steroidogenic outcomes differ in male and female rat pups. Toxicol Sci 88(2):534-544.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased number of anterior-dorsolateral and ventral prostatic buds in different regions of the urogenital sinus in C57BL/6J and TGF-α (-/-) strains of mice on GD 17.5 for 1.0 and 5.0 μg/kg bw

Subjects: C57BL/6J and other mice

Chemical: Dioxin (TCDD)

Low doses tested: 0.2, 1.0, or 5μg/kg bw

Other doses tested: 10, 50, 100 or 150 μg/kg bw

Route of administration: delivered through gavage

Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: gestational day 17.5

Reference [PubMed Link]
Abbott BD, Lin TM, Rasmussen NT, Albrecht RM, Schmid JE, Peterson RE. 2003. Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD. Toxicol Sci 76(2):427-436.