The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative and absolute anogenital distance on post-natal day 30

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by i.p. injection

Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: post-natal days 30 and 60

Reference [PubMed Link]
Weber Lozada K, Keri RA. 2011. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod 85(3):490-497.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative testes and epididymal weight on post-natal day 60. Decreased testicular AR expression on post-natal day 30 and increased AR expression on post-natal day 60. Decreased PCNA positive testicular cells on both post-natal days 30 and 60.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by i.p. injection

Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: post-natal days 30 and 60

Reference [PubMed Link]
Weber Lozada K, Keri RA. 2011. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod 85(3):490-497.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased ventral UGM Cyp1b1 expression with decreased ERK activation in UGE cells.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 5.0 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: gestational day 15.5 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: gestational day 16.5

Reference [PubMed Link]
Vezina CM, Hardin HA, Moore RW, Allgeier SH, Peterson RE. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinus. Toxicol Sci 113(1):198-206.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative and absolute anogenital distance on post-natal day 30

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by i.p. injection

Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: post-natal days 30 and 60

Reference [PubMed Link]
Jin MH, Ko HK, Hong CH, Han SW. 2008. In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse. Yonsei Med J 49(5):843-850.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative testes and epididymal weight on post-natal day 60. Decreased testicular AR expression on post-natal day 30 and increased AR expression on post-natal day 60. Decreased PCNA positive testicular cells on both post-natal days 30 and 60.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by i.p. injection

Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: post-natal days 30 and 60

Reference [PubMed Link]
Jin MH, Ko HK, Hong CH, Han SW. 2008. In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse. Yonsei Med J 49(5):843-850.