The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DEHP)

Decreased testis and seminal vesicle weights. Changes in the developmental capacity of gametes. Decreased sperm count and viability. Decreased LHR and FSHR in the testis.

Subjects: CD-1 mice

Chemical: Phthalates (DEHP)

Low doses tested: 0.05 mg/kg bw/d

Other doses tested: 5.0 mg/kg bw/d

Route of administration: delivered in diet daily

Exposure duration: gestational day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: post-natal days 21-42

Reference [PubMed Link]
Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. 2012. Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring. Endocrinology 153(2):937-948.