The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DEHP)

Increased anogenital distance/body weight ratio in males treated with 5.0 μg/kg

Subjects: CD-1 mice

Chemical: Phthalates (DEHP)

Low doses tested: 0.5, 1.0, 5.0, and 500.0 μg/kg bw/d

Other doses tested: 50000.0, 500,000.0 μg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered orally

Exposure duration: gestational day 9 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 11)

Age of measurement: gestational day 18

Reference [PubMed Link]
Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA. 2012. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol 34(4):614-621.
Study Results Study Details References

Results for Phthalates (DEHP)

Increased anogenital distance/body weight ratio in males treated with 5.0 μg/kg

Subjects: CD-1 mice

Chemical: Phthalates (DEHP)

Low doses tested: 0.5, 1.0, 5.0, and 500.0 μg/kg bw/d

Other doses tested: 50000.0, 500,000.0 μg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered orally

Exposure duration: gestational day 9 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 11)

Age of measurement: gestational day 18

Reference [PubMed Link]
Carr RL, Borazjani A, Ross MK. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122(1):112-120.