The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DBP)

Decreased expression of genes involved in cholesterol transport and steroidogenesis

Subjects: SD rats

Chemical: Phthalates (DBP)

Low doses tested: 0.1 or 1.0 mg/kg bw/d

Other doses tested: 10, 50, 100 or 500 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 12 – gestational day 19 (comparable to human prenatal development from approximately day 1 of week 4 to day 1 of week 11)

Age of measurement: gestational day 19 (near birth)

Reference [PubMed Link]
Lehmann KP, Phillips S, Sar M, Foster PMD, Gaido KW. 2004. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci 81(1):60-68.