The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for PFCs (PFOA)Reduced age to preputial separatation at 1.0, 3.0, 5.0 mg/kg
Subjects: CD-1 mice
Chemical: PFCs (PFOA)
Low doses tested: 1.0, 3.0, 5.0 mg/kg bw/d
Other doses tested: 10.0, 20.0, 40.0 mg/kg bw/d
Route of administration: dissolved in deionized water and delievered through gavage
Exposure duration: gestational day 1 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 9)
Age of measurement: from gestational day 18 through 60 weeks
|Reference [PubMed Link]
Lau C, Thibodeaux JR, Hanson RG, Narotsky MG, Rogers JM, Lindstrom AB, Strynar MJ. 2006. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 90(2):510-518.