The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for PFCs (PFOA)

Reduced age to preputial separatation at 1.0, 3.0, 5.0 mg/kg

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 1.0, 3.0, 5.0 mg/kg bw/d

Other doses tested: 10.0, 20.0, 40.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 1 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 9)

Age of measurement: from gestational day 18 through 60 weeks

Reference [PubMed Link]
Lau C, Thibodeaux JR, Hanson RG, Narotsky MG, Rogers JM, Lindstrom AB, Strynar MJ. 2006. Effects of perfluorooctanoic acid exposure during pregnancy in the mouse. Toxicol Sci 90(2):510-518.