The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased testosterone concentration at highest dose in adulthood

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.025, 0.060, 0.3 μg/kg bw

Other doses tested: Initial dose was followed by weekly maintenance doses (at 20 percent)

Route of administration: injected subcutaneously

Exposure duration: pre-conception – post-natal day 22 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Faqi AS, Chahoud I. 1998. Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation. Bulletin of Environmental Contamination & Toxicology 61(4):462-469.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased level of ovalbumin (OVA) - specific immunoglobulin G and E (IgG and IgE) in plasma of adult offspring

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw on gestational days 0, 7, and 14 and at 2 days of age

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 0 (cross-fostered at 2 days of age) – last dose at 2 days of age (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: eight through 10 weeks of age

Reference [PubMed Link]
Hogaboam JP, Moore AJ, Lawrence BP. 2008 Mar. The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system. Toxicol Sci 102(1):160-70.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased levels of FSH and LH in the F2 and F3 generations and decreased E2 levels in the F1 and F3 generations in females.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 2.0 ng/L

Route of administration: dissolved in DMSO and delivered in drinking water

Exposure duration: gestational day 0 – daily in drinking water (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: post-natal day 1, 4, 21, and 35

Reference [PubMed Link]
Huang L, Huang R, Ran XR, Liu HY, Zhang Y, Dai LJ, Li B. 2011. Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality. J Toxicol Sci 36(6):713-724.