The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased serum thyroid-stimulating hormone (TSH) with no change in T3 or T4

Subjects: Long-Evans rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 20 – single dose (comparable to human prenatal development from approximately day 1 of week 13 to day 1 of week 14)

Age of measurement: 25 days of age

Reference [PubMed Link]
Fenton SE, Hamm JT, Birnbaum LS, Youngblood GL. 2002. Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 67(1):63-74.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased serum level of tumor necrosis factor alpha (TNF-α) 2 days after intraperitoneal injection of Listeria monocytogenes; increased interferon gamma (IFN-γ) level in females at 0.0056 μg/kg 2 days after injection with Listeria monocytogenes

Subjects: C57BL/6NCji mice

Chemical: Dioxin (TCDD)

Low doses tested: 0.00057 or 0.0056 μg/kg bw, total in 17 daily doses

Route of administration: dissolved in drinking water

Exposure duration: birth – 21 days of age (comparable to human prenatal development from approximately day 1 of week 13 to beyond birth)

Age of measurement: 21 days of age

Reference [PubMed Link]
Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y. 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67(1):89-93.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased expression of cytochrome P450 1A1 (CYP1A1) mRNA at 1.0 and 10.0 nM

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 or 10.0 nM

Other doses tested: 100 nM

Route of administration: in vitro culture

Exposure duration: gestational day 20 – single dose (comparable to human prenatal development from approximately day 1 of week 13 to day 1 of week 16)

Age of measurement: 24 hours in culture

Reference [PubMed Link]
Taketoh J, Mutoh J, Takeda T, Ogishima T, Takeda S, Ishii Y, Ishida T, Yamada H. 2007. Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary. Life Sci 80(14):1259-1267.