The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased periosteal circumference, endosteal circumference, and polar cross-sectional moment of inertia of femurs in line C rats at 1.0 μg/kg

Subjects: Line A (least sensitive to TCDD), B, and C (most sensitive) rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.03, 0.1, 0.3, or 1.0 μg/kg bw; exposure timing study

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: 4 days of age – single dose (comparable to human prenatal development from approximately day 1 of week 24 to day 1 of week 25)

Age of measurement: 40 days of age

Reference [PubMed Link]
Miettinen HM, Pulkkinen P, Jamsa T, Koistinen J, Simanainen U, Tuomisto J, Tuukkanen J, Viluksela M. 2005. Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. Toxicol Sci 85(2):1003-1012.