The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DEHP)

Decreased aromatase activity in males at 1 but not 22 days old; increased aromatase activity in females at 22 days but not 1 day old

Subjects: Wistar rats

Chemical: Phthalates (DEHP)

Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d

Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: 1 and 22 days of age

Reference [PubMed Link]
Andrade AJM, Grande SW, Talsness CE, Grote K, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology 227(3):185-192.
Study Results Study Details References

Results for Phthalates (DEHP)

Increased serum testosterone concentration at 0.045 and 0.405 mg/kg

Subjects: Wistar rats

Chemical: Phthalates (DEHP)

Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d

Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: 144 days of age

Reference [PubMed Link]
Andrade AJ, Grande SW, Talsness CE, Gericke C, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Reproductive effects on adult male offspring rats. Toxicology 228(1):85-97.