The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DEHP)

Increased serum testosterone levels in males treated with 0.5, 5.0, and 500.0 μg/kg

Subjects: CD-1 mice

Chemical: Phthalates (DEHP)

Low doses tested: 0.5, 1.0, 5.0, and 500.0 μg/kg bw/d

Other doses tested: 50000.0, 500,000.0 μg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered orally

Exposure duration: gestational day 9 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 11)

Age of measurement: gestational day 18

Reference [PubMed Link]
Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA. 2012. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol 34(4):614-621.
Study Results Study Details References

Results for Phthalates (DEHP)

Increased serum testosterone levels in males treated with 0.5, 5.0, and 500.0 μg/kg

Subjects: CD-1 mice

Chemical: Phthalates (DEHP)

Low doses tested: 0.5, 1.0, 5.0, and 500.0 μg/kg bw/d

Other doses tested: 50000.0, 500,000.0 μg/kg bw/d

Route of administration: dissolved in tocopherol-stripped corn oil and administered orally

Exposure duration: gestational day 9 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 11)

Age of measurement: gestational day 18

Reference [PubMed Link]
Carr RL, Borazjani A, Ross MK. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122(1):112-120.