The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Increased cholesterol and triglyceride levels in males; increased insulin levels in non-fasted males

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 20 to day 1 of week 25)

Age of measurement: 110 days of age

Reference [PubMed Link]
Slotkin TA, Brown KK, Seidler FJ. 2005. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ Health Perspect 113(10):1291-1294.