The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative spleen weight for males at 0.0056 μg/kg; increased number of bacteria in female spleen 2 days after intraperitoneal injection with Listeria monocytogenes

Subjects: C57BL/6NCji mice

Chemical: Dioxin (TCDD)

Low doses tested: 0.00057 or 0.0056 μg/kg bw, total in 17 daily doses

Route of administration: dissolved in drinking water

Exposure duration: birth – 21 days of age (comparable to human prenatal development from approximately day 1 of week 13 to beyond birth)

Age of measurement: 21 days of age

Reference [PubMed Link]
Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y. 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67(1):89-93.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased number of CD4 positive thymus cells in males at 0.0056 μg/kg

Subjects: C57BL/6NCji mice

Chemical: Dioxin (TCDD)

Low doses tested: 0.00057 or 0.0056 μg/kg bw, total in 17 daily doses

Route of administration: dissolved in drinking water

Exposure duration: birth – 21 days of age (comparable to human prenatal development from approximately day 1 of week 13 to beyond birth)

Age of measurement: 21 days of age

Reference [PubMed Link]
Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y. 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67(1):89-93.