The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative thymus weight at 67 days of age with in utero only exposure

Subjects: C57BL/6N mice

Chemical: Dioxin (TCDD)

Low doses tested: 3.0 μg/kg bw

Other doses tested: 12.0μg/kg

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 and cross-fostered at birth – single dose (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 3)

Age of measurement: birth through 67 days of age

Reference [PubMed Link]
Couture-Haws L, Harris MW, Lockhart AC, Birnbaum LS. 1991. Evaluation of the persistence of hydronephrosis induced in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 107(3):402-412.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased thymic weight at gestational day 18; decreased thymic cellularity (cell yield per thymus) at gestational day 18 and at 6 days of age; significantly altered patterns of thymocyte expression of cell surface antigens CD4 and CD8 at gestational day 18 and 6 days of age but not 14 days of age; depressed cytotoxic T lymphocyte activity at 8 weeks of age

Subjects: C57BL/6N mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.5 or 3.0 μg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 – gestational day 14 (and cross fostered after birth) (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: gestational day 18 and post-natally through 10 weeks of age

Reference [PubMed Link]
Holladay SD, Lindstrom P, Blaylock BL, Comment CE, Germolec DR, Heindell JJ, Luster MI. 1991. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 44(4):385-393.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased CD4-8- and CD4-8+ thymocytes; decreased CD4+8+ thymocytes; decreased TCRαβ and increased TCRγδ at higher dose; decrease in small cell population with relative increase in larger (less mature) cells

Subjects: B6C3F1 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.5 or 3.0 μg/kg bw/d

Route of administration: not specified

Exposure duration: gestational day 6 – gestational day 14 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 11)

Age of measurement: gestational day 18

Reference
Luster MI, Holladay SD, Blaylock BL, Germolec DR, Clark GC, Comment CE, Heindel JJ, Rosenthal GJ. 1992. TCDD inhibits murine thymocyte and B lymphocyte maturation. Chemosphere 25(1-2):115-118.