The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased thymus weight

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 3.0 μg/kg/bw

Other doses tested: 0, 3, or 10 μg/kg/bw at 77 days of age, again 21 days later at time of surgery, and at intervals 3, 6, and 9 weeks after surgery

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 8 – adulthood (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Cummings AM, Hedge JM, Birnbaum LS. 1999. Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice. Toxicol Sci 52(1):45-49.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased thymus weight at 1.0 μg/kg

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.25 or 1.0 μg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 10 – gestational day 16 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: 21 days of age

Reference [PubMed Link]
Seo BW, Li MH, Hansen LG, Moore RW, Peterson RE, Schantz SL. 1995. Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats. Toxicol Lett 78(3):253-262.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased thymus weight

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.1 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 10 – gestational day 16 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: birth through 80 days of age

Reference [PubMed Link]
Seo BW, Sparks AJ, Medora K, Amin S, Schantz SL. 1999. Learning and memory in rats gestationally and lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicology & Teratology 21(3):231-239.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative thymus weight at weaning at 0.2 μg/kg

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.1 or 0.2 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 10 – gestational day 16 (comparable to human prenatal development from approximately day 1 of week 3 to beyond birth)

Age of measurement: birth through young adulthood

Reference [PubMed Link]
Seo BW, Powers BE, Widholm JJ, Schantz SL. 2000. Radial arm maze performance in rats following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Neurotoxicology & Teratology 22(4):511-519.