The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Varying effects on thymocytes at different stages of development.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 0.5, 1.0, or 10.0 nM

Route of administration: in vitro culture

Exposure duration: post-natal day 15 – 7 days in vitro culture (comparable to human prenatal development from approximately day 1 of week 32 to beyond birth)

Age of measurement: 7 days culture

Reference [PubMed Link]
Lai ZW, Fiore NC, Gasiewicz TA, Silverstone AE. 1998. 2,3,7,8-tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicology & Applied Pharmacology 149(2):167-177.
Study Results Study Details References

Results for Dioxin (TCDD)

Varying effects on thymocyte differentiation, proliferation and apoptosis.

Subjects: bcl-2 transgenic mice

Chemical: Dioxin (TCDD)

Low doses tested: 10.0 nM

Route of administration: in vitro culture

Exposure duration: post-natal day 15 – 7 days in vitro culture (comparable to human prenatal development from approximately day 1 of week 32 to beyond birth)

Age of measurement: 7 days culture

Reference [PubMed Link]
Lai ZW, Fiore NC, Hahn PJ, Gasiewicz TA, Silverstone AE. 2000. Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicology & Applied Pharmacology 168(1):15-24.