The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased lymph node cellularity in females esposed to 2.5 μg/kg at 48 weeks of age. Alterations in bone marrow B lymphoid progenitor types in males and females at both exposure groups. Changes in thymic T cell differentiation and splenic B cell and lymph node T cell population distributions in males and females at 5.0 μg/kg. Males exposed to 5.0 μg/kg had increased levels of anti-cardiolipin autoantibodies. At 5.0 μg/kg there were increased INF-γ levels in females and increased IL-10 levels in males.

Subjects: C57BL/6J mice

Chemical: Dioxin (TCDD)

Low doses tested: 2.5 or 5.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: 48 weeks of age

Reference [PubMed Link]
Mustafa A, Holladay SD, Witonsky S, Sponenberg DP, Karpuzoglu E, Gogal RM Jr. 2011. A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology 290(2-3):156-168.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased thymus weight and cellularity in females exposed to 5.0 μg/kg at 48 weeks of age

Subjects: C57BL/6J mice

Chemical: Dioxin (TCDD)

Low doses tested: 2.5 or 5.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: 48 weeks of age

Reference [PubMed Link]
Mustafa A, Holladay SD, Witonsky S, Sponenberg DP, Karpuzoglu E, Gogal RM Jr. 2011. A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology 290(2-3):156-168.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased relative spleen weight on post-natal day 14. Alterations in the expression of CD44 and CD45/CD90 on post-natal days 1 and 46 respectively.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 5.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: post-natal days 1, 14, 25, and 46

Reference [PubMed Link]
Weinstein DA, Gogal RM Jr, Mustafa A, Prater MR, Holladay SD. 2008. Mid-gestation exposure of C57BL/6 mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes postnatal morphologic changes in the spleen and liver. Toxicol Pathol 36(5):705-713.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative thymus weight on post-natal day 1. Increased thymic apoptic index on post-natal day 1.

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 5.0 μg/kg bw

Route of administration: dissolved in corn oil and administered by gavage

Exposure duration: gestational day 12 – single dose (comparable to human prenatal development from approximately day 1 of week 5 to day 1 of week 6)

Age of measurement: post-natal days 1, 14, 25, and 46

Reference [PubMed Link]
Weinstein DA, Gogal RM Jr, Mustafa A, Prater MR, Holladay SD. 2008. Mid-gestation exposure of C57BL/6 mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin causes postnatal morphologic changes in the spleen and liver. Toxicol Pathol 36(5):705-713.