The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased level of adseverin/HPRT (human hypoxanthine phosphoribosyltransferse) mRNA in thymocytes and whole thymus; increased level of cytochrome P450 1A1 (CYP1A1)/HPRT mRNA in thymocytes, whole thymus and thymic stroma

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 10 nM

Route of administration: in vitro culture

Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: 24 hours in culture

Reference [PubMed Link]
Svensson C, Silverstone AE, Lai ZW, Lundberg K. 2002. Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor. Biochem Biophys Res Commun 291(5):1194-1200.