The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Decreased mitogenic response of T-cells on post-natal day 60 across two doses of concanavalin A

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 1 – post-natal day 4 (comparable to human prenatal development from approximately day 1 of week 20 to day 1 of week 25)

Age of measurement: post-natal day 5 and 60

Reference [PubMed Link]
Navarro HA, Basta PV, Seidler FJ, Slotkin TA. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect? Developmental Brain Research 130(2):249-252.
Study Results Study Details References

Results for Chlorpyrifos

Increased lipid peroxidation at 1.0 and 1.35 mg/kg; decreased superoxide dismutase and glutathione-s-transferase at 1.35 mg/kg; (all measures of oxidative stress).

Subjects: Wistar rats

Chemical: Chlorpyrifos

Low doses tested: 0.01, 1.0 or 1.35 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered via oral gavage

Exposure duration: post-natal day 1 – post-natal day 20 (comparable to human prenatal development from approximately day 1 of week 20 to beyond birth)

Age of measurement: post-natal day 21

Reference [PubMed Link]
Mansour SA, Mossa AH. 2010. Adverse effects of lactational exposure to chlorpyrifos in suckling rats. Human & Experimental Toxicology 29(2):77-92.