The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Bisphenol A

Decreased body weight in both males and females on post-natal day 21-22

Subjects: ICR/Jcl mice

Chemical: Bisphenol A

Low doses tested: 20.0 μg/kg bw/d

Route of administration: dissolved in sesame oil and delivered subcutaneously

Exposure duration: embryronic day 0 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: post-natal day 21-22 and post-natal week 10

Reference [PubMed Link]
Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S. 2012. Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior. Brain Dev 34(1):57-63.
Study Results Study Details References

Results for Bisphenol A

Increased rate of development from 2 to 8 cells at two lower doses (with decreased development at 100 μM )

Subjects: B6C3F1 mouse embryos

Chemical: Bisphenol A

Low doses tested: 1 nM or 3 nM or 100 μM

Route of administration: added in vitro to two-cell embryos

Exposure duration: gestational day 2 – gestational day 4 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 2)

Age of measurement: in vitro at 3 and 4 days post-fertilization

Reference [PubMed Link]
Takai Y, Tsutsumi O, Ikezuki Y, Hiroi H, Osuga Y, Momoeda M, Yano T, Taketani Y. 2000. Estrogen receptor-mediated effects of a xenoestrogen, bisphenol A, on preimplantation mouse embryos. Biochemical & Biophysical Research Communications 270(3):918-921.
Study Results Study Details References

Results for Bisphenol A

Increased body weight 21 days after birth

Subjects: B6C3F1 mouse embryos

Chemical: Bisphenol A

Low doses tested: 1 nM

Route of administration: added in vitro to two-cell embryos

Exposure duration: gestational day 2 – gestational day 4 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 2)

Age of measurement: in vitro at 4 days post-fertilization, then in vivo at birth and 21 days of age

Reference [PubMed Link]
Takai Y, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Yano T, Taketan Y. 2001. Preimplantation exposure to bisphenol A advances postnatal development. Reprod Toxicol 15(1):71-74.
Study Results Study Details References

Results for Bisphenol A

Increased rate of development from 2 to 8 cells in vitro

Subjects: B6C3F1 mouse embryos

Chemical: Bisphenol A

Low doses tested: 1 nM

Route of administration: added in vitro to two-cell embryos

Exposure duration: gestational day 2 – gestational day 4 (comparable to human prenatal development from approximately day 1 of week 1 to day 1 of week 2)

Age of measurement: in vitro at 4 days post-fertilization, then in vivo at birth and 21 days of age

Reference [PubMed Link]
Takai Y, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Yano T, Taketan Y. 2001. Preimplantation exposure to bisphenol A advances postnatal development. Reprod Toxicol 15(1):71-74.