The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Decreased body weight at 7 days of age at both doses and additionally at 14, 21 and 31 days of age at the higher dose

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 1.0 μg/kg bw

Other doses tested: Initial dose was followed by weekly maintenance doses (at 40 percent)

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – adulthood (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Thiel R, Koch E, Ulbrich B, Chahoud I. 1994. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin - effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69(2):79-86.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased body weight at 3.0 μg/kg

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 3.0 μg/kg bw

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11)

Age of measurement: 77 days of age

Reference
Korte M, Stahlmann R, Thiel R, Nagao T, Chahoud I, Vanloveren H, Vos JG, Neubert D. 1991. Resistance to trichinella-spiralis infection, induction of hepatic monooxygenases, and concentrations in thymus and liver in rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 23(11-12):1845-1854.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative liver weight

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 3.0 μg/kg bw

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11)

Age of measurement: 77 days of age

Reference
Korte M, Stahlmann R, Thiel R, Nagao T, Chahoud I, Vanloveren H, Vos JG, Neubert D. 1991. Resistance to trichinella-spiralis infection, induction of hepatic monooxygenases, and concentrations in thymus and liver in rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 23(11-12):1845-1854.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased EROD activity in liver homogenate in post-natally exposed conditions only

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.003, 0.03, or 0.3 μg/kg bw

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 and cross-fostered at birth – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11)

Age of measurement: 2 through 21 days of age

Reference
Korte M, Stahlmann R, Neubert D. 1990. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD tissue concentrations after single treatment during pregnancy. Chemosphere 20(7-9):1193-1198.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased body weight of males and females

Subjects: Line C (highly sensitive to TCDD) rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered orally

Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11)

Age of measurement: 40 days of age

Reference [PubMed Link]
Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased relative body weight at 42 through 84 days of age at loading and maintenance doses of 0.3 and 0.12 μg/kg respectively

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 μg/kg bw

Other doses tested: loading dose of 1.0 μg/kg and maintenance doses of 0.12 or 0.4 μg/kg

Route of administration: dissolved in corn oil and injected subcutaneously

Exposure duration: gestational day 19 – 12 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth)

Age of measurement: 42 through 84 days of age

Reference [PubMed Link]
Neubert R, Stahlmann R, Korte M, Vanloveren H, Vos JG, Golor G, Webb JR, Helge H, Neubert D. 1993. Effects of small doses of dioxins on the immune-system of marmosets and rats. Ann N Y Acad Sci 685:662-686.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased body weight at 14, 21, and 31 days of age at 1.0 μg/kg

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 1.0 μg/kg bw initial dose, with 0.4 or 0.12 μg/kg weekly maintenance doses

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – at 5 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth)

Age of measurement: 7 through 31 days of age

Reference
Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased (delayed) fur development at 7 days of age

Subjects: Wistar rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.3 or 1.0 μg/kg bw initial dose, with 0.4 or 0.12 μg/kg weekly maintenance doses

Route of administration: injected subcutaneously

Exposure duration: gestational day 19 – at 5 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth)

Age of measurement: 7 through 31 days of age

Reference
Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231.