The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Altered expression of a number of genes involved in xenobiotic metabolism, cardiac homeostasis, extracellular matrix production/remodeling and cell cycle regulation

Subjects: C57B16N mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.5 or 3.0 μg/kg bw/d

Other doses tested: 6.0 μg/kg bw/d

Route of administration: dissolved in corn oil and fed via gavage

Exposure duration: gestational day 14.5 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: gestational day 17.5

Reference [PubMed Link]
Thackaberry EA, Jiang Z, Johnson CD, Ramos KS, Walker MK. 2005a. Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes. Toxicol Sci 88(1):231-41.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative heart weight at 3.0 μg/kg

Subjects: C57B16N mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.5 or 3.0 μg/kg bw/d

Other doses tested: 6.0, 12 or 24 μg/kg bw/d

Route of administration: dissolved in corn oil and fed via gavage

Exposure duration: gestational day 14.5 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: gestational day 17.5

Reference [PubMed Link]
Thackaberry EA, Nunez BA, Ivnitski-Steele ID, Friggins M, Walker MK. 2005b. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy. Toxicol Sci 88(1):242-9.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased relative liver weight

Subjects: C57B16N mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.5 or 3.0 μg/kg bw/d

Other doses tested: 6.0, 12 or 24 μg/kg bw/d

Route of administration: dissolved in corn oil and fed via gavage

Exposure duration: gestational day 14.5 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: gestational day 17.5

Reference [PubMed Link]
Thackaberry EA, Nunez BA, Ivnitski-Steele ID, Friggins M, Walker MK. 2005b. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy. Toxicol Sci 88(1):242-9.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased expression of cardiac cytochrome P450 1A1 (CYP1A1) mRNA, and cardiac matrix metalloprotenase 13 (MMP13) mRNA, and preproentothelin - 1 (prepro ET-1) mRNA, and cardiac osteopontin (OPN) mRNA at 3.0 μg/kg; increased expression of cardiac aryl hydrocarbon receptor regulator (AHRR) mRNA, and cardiac atrial natriuretic peptide (ANP) mRNA, and cardiac β-myosin heavy chain (β-MHC) mRNA at 1.5 and 3.0 μg/kg

Subjects: AHR +/+ C57BL/6N mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.5 or 3.0 μg/kg bw

Other doses tested: 6.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 14.5 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8)

Age of measurement: gestational day 17.5

Reference [PubMed Link]
Aragon AC, Kopf PG, Campen MJ, Huwe JK, Walker MK. 2008. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol Sci 101(2):321-330.