The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Dioxin (TCDD)

Increased body weight at some doses and time points with results varying by sex

Subjects: Holtzman rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.02, 0.6 or 0.18 μg/kg

Route of administration: dissolved in olive oil and delivered through gavage

Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)

Age of measurement: birth through young adulthood

Reference [PubMed Link]
Markowski VP, Zareba G, Stern S, Cox C, Weiss B. 2001. Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 109(6):1-7.
Study Results Study Details References

Results for Dioxin (TCDD)

Increased mortality at day 1 after birth

Subjects: Holtzman rats

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Flaws JA, Sommer RJ, Silbergeld EK, Peterson RE, Hirshfield AN. 1997. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicology & Applied Pharmacology 147(2):351-362.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased weights in treated males at 60 days of age

Subjects: Dark-Agouti rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.7 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)

Age of measurement: post-natal days 1, 14 and 60

Reference [PubMed Link]
Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766.
Study Results Study Details References

Results for Dioxin (TCDD)

Reduced litter size and decreased number of females in litters

Subjects: Dark-Agouti rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.7 μg/kg bw

Route of administration: dissolved in corn oil and administered orally

Exposure duration: gestational day 18 – single dose (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 9)

Age of measurement: post-natal days 1, 14 and 60

Reference [PubMed Link]
Tomasini MC, Beggiato S, Ferraro L, Tanganelli S, Marani L, Lorenzini L, Antonelli T. 2012. Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex. Neurochem Int 61(5):759-766.