The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Phthalates (DEHP)

Increased body weight in females at birth at 0.045 mg/kg; increased body weight in females at three time points at 1.215 mg/kg

Subjects: Wistar rats

Chemical: Phthalates (DEHP)

Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d

Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: from birth through first estrus

Reference [PubMed Link]
Grande SW, Andrade AJM, Talsness CE, Grote K, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: Effects on female rat reproductive development. Toxicol Sci 91(1):247-254.
Study Results Study Details References

Results for Phthalates (DEHP)

Increased body weight at several doses and time points

Subjects: Wistar rats

Chemical: Phthalates (DEHP)

Low doses tested: 0.015, 0.045, 0.135, 0.405 or 1.215 mg/kg bw/d

Other doses tested: 5, 15, 45, 135 or 405 mg/kg bw/d

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: from birth through weaning

Reference [PubMed Link]
Andrade AJM, Grande SW, Talsness CE, Grote K, Golombiewski A, Sterner-Kock A, Chahoud I. 2006. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 225(1):64-74.