The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Decreased body weight at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 0.3, 1.0, or 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 31)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Maurissen JPJ, Hoberman AM, Garman RH, Hanley TR. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol Sci 57(2):250-263.
Study Results Study Details References

Results for Chlorpyrifos

Decreased survival rate between birth and 4 days of age at 5 mg/kg; delayed pinna detachment at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 0.3, 1.0, or 5.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 6 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 31)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Maurissen JPJ, Hoberman AM, Garman RH, Hanley TR. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol Sci 57(2):250-263.
Study Results Study Details References

Results for Chlorpyrifos

Increased post-weaning body weight among males

Subjects: Long Evans rats

Chemical: Chlorpyrifos

Low doses tested: 2.5 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered through gavage

Exposure duration: gestational day 7 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 16)

Age of measurement: birth through adulthood

Reference [PubMed Link]
Lassiter TL, Brimijoin S. 2008. Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos. Neurotoxicology & Teratology 30(2):125-130.