The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Varied effects on adenylyl cyclase activity

Subjects: Zivic Miller Lab rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Other doses tested: 1 mg/kg on pnd 1-4

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: 15 and 20 days of age

Reference [PubMed Link]
Auman JT, Seidler FJ, Slotkin TA. 2000. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Developmental Brain Research 121(1):19-27.
Study Results Study Details References

Results for Chlorpyrifos

Decreased body weight across post-natal day 15 and 20 with a more marked decreased on post-natal day 15

Subjects: Unspecified strain rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Other doses tested: 25 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: post-natal day 15 through 20

Reference [PubMed Link]
Campbell CG, Seidler FJ, Slotkin TA. 1997. Chlorpyrifos interferes with cell development in rat brain regions. Brain Res Bull 43(2):179-189.
Study Results Study Details References

Results for Chlorpyrifos

Decreased Beta-adrenergic receptor binding in the liver at post-natal day 60

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: post-natal day 15, 20, 60

Reference [PubMed Link]
Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178.
Study Results Study Details References

Results for Chlorpyrifos

Increased levels of thiobarbituric acid-reactive species

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: post-natal day 15

Reference [PubMed Link]
Slotkin TA, Oliver CA, Seidler FJ. 2005. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Developmental Brain Research 157(2):172-180.
Study Results Study Details References

Results for Chlorpyrifos

Increased levels of thiobarbituric acid-reactive species at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: post-natal day 15

Reference [PubMed Link]
Slotkin TA, Oliver CA, Seidler FJ. 2005. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Developmental Brain Research 157(2):172-180.
Study Results Study Details References

Results for Chlorpyrifos

Decreased βAR binding at post-natal days 45 and 60; reduced adenylyl cyclase in males but increased in females

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: post-natal day 21, 30, 45 and 60

Reference [PubMed Link]
Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2005. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Developmental Brain Research 160(2):219-230.
Study Results Study Details References

Results for Chlorpyrifos

Increased heart basal adenylyl cyclase activity at 15 days of age; decreased heart basal adenylyl cyclase activity at 20 days of age in the presence and absence of G-proteins (GTP); increased heart fluoride-stimulated adenylyl cyclase activity at 20 days of age; increased heart isoproterenol-stimulated adenylyl cyclase activity at 15 days of age; decreased heart βreceptor binding capability at 20 days of age

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected sub-cutaneously

Exposure duration: post-natal day 11 – post-natal day 14 (comparable to human prenatal development from approximately day 1 of week 31 to day 1 of week 35)

Age of measurement: 15 and 20 days of age

Reference [PubMed Link]
Song X, Seidler FJ, Saleh JL, Zhang J, Padilla S, Slotkin TA. 1997. Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade. Toxicology & Applied Pharmacology 145(1):158-174.