The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for Chlorpyrifos

Increased Beta-adrenergic receptor binding in the heart of males at post-natal day 60 at 1 mg/kg; increased basal, isoproterenol and forskolin induced activity of adenylyl cyclase in the heart of females at 1 mg/kg and 5 mg/kg; increased sodium fluoride (NaF) induced activity of adenylyl cyclase in the heart of females at post-natal day 60 at 5 mg/kg; decreased isoproterenol, glucagon, NaF and forskolin induced activity of adenylyl cyclase in the heart of males at post-natal day 60 at 5 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d

Other doses tested: 10, 20 or 40 mg/kg

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 17 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 14)

Age of measurement: gestational day 21 and post-natal day 60

Reference [PubMed Link]
Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178.
Study Results Study Details References

Results for Chlorpyrifos

Decreased glucagon and forskolin induced activity of adenylyl cyclase in the liver at post-natal day 60 at 1 mg/kg

Subjects: Sprague-Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0, 2.0 or 5.0 mg/kg bw/d

Other doses tested: 10, 20 or 40 mg/kg

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 17 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 14)

Age of measurement: gestational day 21 and post-natal day 60

Reference [PubMed Link]
Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178.
Study Results Study Details References

Results for Chlorpyrifos

Decreased norepinephrine levels at 1.0 and 5.0 mg/kg at post-natal day 60

Subjects: Sprague Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 17 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 14)

Age of measurement: post-natal days 30 and 60

Reference [PubMed Link]
Seidler FJ, Slotkin TA. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids. Brain Res Bull 85(3-4):225-230.
Study Results Study Details References

Results for Chlorpyrifos

Decreased norepinephrine levels at 5.0 mg/kg at post-natal day 60

Subjects: Sprague Dawley rats

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 17 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 14)

Age of measurement: post-natal days 30 and 60

Reference [PubMed Link]
Seidler FJ, Slotkin TA. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids. Brain Res Bull 85(3-4):225-230.